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IXèmes Journées Annuelles de la Société française de Myologie (SFM) (3-5 novembre 2011; Angers) ; Kostallari E ; Baba-Amer Y ; Lafuste P ; Gherardi RK | 2011INTRODUCTION : Le muscle squelettique comporte deux types principaux de cellules souches : les cellules satellites musculaires (CSm) et les cellules souches mésenchymateuses interstitielles. Les CSm sont nichées à l'état quiescent sous la lame b[...]Article
IXèmes Journées Annuelles de la Société française de Myologie (SFM) (3-5 novembre 2011; Angers) ; Mayeuf A ; Vincent S ; Lagha M ; Anne D ; Relaix F ; Kume T ; Buckingham M | 2011Vertebrate skeletal muscles derive from transitory mesodermal structures called somites. Within the dorsal part of the somite, the dermomyotome, there are progenitors that express the transcription factor Pax3. The dermomyotome gives rise to the[...]Article
Harmon EB ; Harmon ML ; Larsen TD ; Yang J ; Glasford JW ; Perryman MB | 2011Accès au résumé PubMed / to PubMed abstractArticle
Dmitriev P ; Petrov A ; Ansseau E ; Stankevicins L ; Charron S ; Li Ah Kim E ; Bos TJ ; Robert T ; Turki A ; Coppée F ; Belayew A ; Lazar V ; Carnac G ; Laoudj D ; Lipinski M ; Vassetzky YS | 2011Accès au résumé PubMed / to PubMed abstractArticle
Zucconi E ; Vieira NM ; Bueno CR, Jr ; Secco M ; Jazedje T ; Costa Valadares M ; Fussae Suzuki M ; Bartolini P ; Vainzof M ; Zatz M | 2011Accès au résumé PubMed / to PubMed abstractArticle
Dedeic Z ; Cetera M ; Cohen TV ; Holaska JM | 2011Accès au résumé PubMed / to PubMed abstractArticle
Rousseau J ; Chapdelaine P ; Boivert S ; Almeida LP ; Corbeil J ; Montpetit A ; Tremblay JP | 2011Accès au résumé PubMed / to PubMed abstractArticle
Muscle cell formation is a coordinated process of tissue-specific gene expression, proliferation and differentiation. In order to safeguard the developing progenitor cells against a prolonged proliferation or a premature differentiation, cell cy[...]Article
Erratico S ; Villa C ; Razini P ; Cassinelli LM ; Parolini D ; Meregalli M ; Belicchi M ; Torrente Y | AFM-TELETHON | 2011Peripheral blood is a promising alternative source of stem cells for transplantation for the treatment of different malignancies. Using CD133, as a marker of stemness, we identified a subpopulation of purified blood-derived stem cells which diff[...]Article
During embryonic development and embryonic stem cell (ESC) differentiation, the different cells forming the mature heart arise from the differentiation of two types of multipotent cardiovascular progenitors (MCPs). Using mouse embryonic stem cel[...]Guide
The objectives of the muscular disease team are to explore and validate the potential of human and dog pluripotent stem cells - human Embryonic Stem (hES) cells and induced Pluripotent Stem (iPS) cells - and their differentiated progenies to des[...]Article
Logan CV ; Lucke B ; Pottinger C ; Abdelhamed ZA ; Parry DA ; Szymanska K ; Diggle CP ; van Riesen A ; Morgan JE ; Markham G ; Ellis I ; Manzur AY ; Markham AF ; Shires M ; Helliwell T ; Scoto M ; Hübner C ; Bonthron DT ; Taylor GR ; Sheridan E ; Muntoni F ; Carr IM ; Schuelke M ; Johnson CA | 2011Article
Our aim is to understand how skeletal muscle form and grow during vertebrate embryonic development. The early skeletal muscle (the primary myotome, composed of mononucleated, post-mitotic muscle fibers, the myocytes) is formed from the generatio[...]Article
Aguennouz M ; Vita GL ; Messina S ; Cama A ; Lanzano N ; Ciranni A ; Rodolico C ; Di Giorgio RM ; Vita G | 2011Accès au résumé PubMed / to PubMed abstract 09/03/2010 - Surexpression de TRF1 et de PARP1 dans la dystrophie musculaire de Duchenne La dystrophie musculaire de Duchenne (DMD) est due à des mutations dans le gène DMD responsables [...]Article
Shi ST ; Hoogaars WMH ; de Gorter DJJ ; van Heiningen SH ; Lin HY ; Hong CC ; Kemaladewi DU ; Aartsma Rus A ; Ten Dijke P ; 't Hoen PAC | 2011Accès au résumé PubMed / to PubMed abstract 02/12/2010 - Succès des antagonistes aux BMP chez les souris modèles de dystrophie musculaire de Duchenne La dystrophie musculaire de Duchenne (DMD) est caractérisée par une dégénérescenc[...]Article
Kueh SLL ; Dempster J ; Head SI ; Morley JW | 2011Accès au résumé PubMed / to PubMed abstractGuide
The group’s objectives are focused on using neural progenies of human Pluripotent Stem (hPS) cells to better understand and develop new treatments for Huntington Disease (HD). This devastating neurodegenerative disorder belongs to a family of ge[...]Guide
The lack of pertinent models for neuromuscular disorders has rendered many important questions in disease pathogenesis inaccessible. Current drugs provide only limited benefit by alleviating certain symptoms. Clearly, the development of efficaci[...]Article
Guide
The term “neuroplasticity” refers to the ability of the human brain to change as a result of one’s experience. This capacity of adaptation results from the production of new neurons, the addition or removing of connections between neurons or of [...]Guide
Ischemic stroke is a leading cause of death and long-term disability, and accounts for a large proportion of the health care costs in industrialized countries. Although stroke is mainly of polygenic origin, a large number of single-gene disorder[...]Article
Mafi R ; Hindocha S ; Mafi P ; Griffin M ; Khan WS | 2011Accès au résumé PubMed / to PubMed abstractGuide
Induced Pluripotent Stem (iPS) cells harbour the same characteristics and capabilities as embryonic stem cells without carrying their ethical constraints. They offer the opportunity on the one hand to model diseases for which there are no availa[...]Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Lepper C ; Partridge T ; Chen-Ming F | AFM-TELETHON | 2011Skeletal muscle tissue is prone to damage from acute physical trauma such as sport injuries as well as from daily wear and tear: this is managed by its tremendous capacity to repair itself. Cell transplantation and lineage tracing studies have d[...]Article
Sciorati C ; Miglietta D ; Buono R ; Pisa V ; Cattaneo D ; Azzoni E ; Brunelli S ; Clementi E | 2011Accès au résumé PubMed / to PubMed abstract 28/08/2011 - Le NCX 320, un dérivé de l’ibuprofène, permet de ralentir la progression de la dystrophie musculaire à long-terme chez la souris L’oxide nitrique (NO) est impliqué dans la p[...]Article
AFM-TELETHON 2011Mesoangioblasts are recently characterized progenitor cells, associated with the vasculature and able to differentiate into different types of solid mesoderm, including skeletal muscle (Minasi et al. Development 129, 2773, 2002). When wild type [...]Article
Wang B ; Miyagoe-Suzuki Y ; Yada E ; Ito N ; Nishiyama T ; Nakamura M ; Ono Y ; Motohashi N ; Segawa M ; Masuda S ; Takeda S | 2011Accès au résumé PubMed / to PubMed abstractArticle
Moorwood C ; Lozynska O ; Suri N ; Napper AD ; Diamond SL ; Khurana TS | 2011Accès au résumé PubMed / to PubMed abstract 02/02/2012 - Le nabumetone, une nouvelle molécule qui augmente l’expression de l’utrophine dans des cultures de cellules La dystrophie musculaire de Duchenne (DMD), liée à une mutation dans[...]Article
Cheli S ; François S ; Bodega B ; Ferrari F ; Tenedini E ; Roncaglia E ; Ferrari S ; Ginelli E ; Meneveri R | 2011Accès au résumé PubMed / to PubMed abstractArticle
Vanderplanck C ; Ansseau E ; Charron S ; Stricwant N ; Tassin A ; Laoudj-Chenivesse D ; Wilton SD ; Coppée F ; Belayew A | 2011Accès au résumé PubMed / to PubMed abstractArticle
AFM-TELETHON 2011The lack of existing models of pathologic tissues has rendered many important questions in disease pathogenesis inaccessible. Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the tec[...]Article
Valadares M ; Zucconi E ; Secco M ; Bueno Junior C ; Brandalise V ; Assoni A ; Gomes J ; Landini V ; Andrade T ; Lima B ; Vainzof M ; Zatz M | AFM-TELETHON | 2011The possibility to use stem-cells in the future as a therapy for progressive muscular dystrophies has been of great interest. However, many questions still need to be addressed. What is the best way of delivery: local or systemic? What are the b[...]Article
AFM-TELETHON 2011During development, founder stem cells proliferate, and cell cycle exit is generally restricted to differentiating cells. In contrast, adult stem cells, can assume different cellular states, either quiescence or proliferating. After embryonic de[...]Thesis
Lescroart F, Author | 2011Le développement cardiaque implique deux lignages cellulaires, dont un correspond au second champ cardiaque qui contribue aux pôles veineux et artériel du coeur. De manière intéressante, une partie des muscles squelettiques antérieurs, non-somit[...]Institutional report
Institutional report
European Medicines Agency | 2011Le but de cette réflexion est de couvrir tous les aspects relatifs aux produits médicaux issus des cellules souches en vue du "Marketing Authorisation Application".Guide
The retina contains photoreceptors that convert light signals into electric signals, further transmitted to the brain by different neurons. Any defect involved in these processes of phototransduction and transmission in the retina lead to visual[...]Article
Cacchiareli D ; Cazzella V ; Cesana M ; Incitti T ; Pinnaro C ; Legnini I ; Morlando M ; Bozzoni I | AFM-TELETHON | 2011MicroRNAs are recognized as important regulators of gene expression in the differentiation commitment of several cell types and have been shown to occupy very high hierarchical positions in the cascade of regulatory events controlling cell speci[...]Article
The plasminogen activation (PA) system is a mechanism extensively used by the cell for the generation of proteolytic activity in the extracellular matrix, where it contributes to tissue remodeling in a wide range of physiopathological processes.[...]Article
Tedesco FS ; Hoshiya H ; D'Antona G ; Gerli MFM ; Messina G ; Antonini S ; Tonlorenzi R ; Benedetti S ; Berghella L ; Torrente Y ; Kazuki Y ; Bottinelli R ; Oshimura M | 2011Accès au résumé PubMed / to PubMed abstract 29/09/2011 - La thérapie génique par chromosomes artificiels humains de cellules souches améliore la dystrophie musculaire de Duchenne dans le modèle de souris mdx Les chromosomes artifici[...]Article
Six1 and Six4 are homeoproteins of the Six/sine oculis family. These proteins are expressed continuously during muscle development: in the dermomyotomal hypaxial myogenic progenitors, they control Pax3 expression and myogenic progenitors fate; i[...]Article
Mesirca P ; Torrente A ; Arsic N ; Nargeot J ; Mangoni M ; Lamb N ; Fernandez A | AFM-TELETHON | 2011Adult stem cells can be isolated from skeletal muscle and display spontanous multi-lineage differentiation including towards cardiac lineage. (Arsic et al. 2008)*. Before differentiation and in addition to Sca-1 and Bcrp1/ABCG2, skeletal Muscle-[...]Article
AFM-TELETHON 2011Environment of stem cells plays a crucial role in controlling their fate: quiescence, proliferation, differentiation, self-renewal. Environment of satellite cells comprise endothelial cells, periendothelial cells, immune cells and fibroblastic c[...]Guide
Our research and development programs are organized into 3 main activities: - Biobanking of human Embryonic Stem (hES) cell lines - Cell culture automation of human Pluripotent Stem (hPS) cells and their progenies - Genomic engineering of hiP[...]Article
Farini A ; Belicchi M ; Parolini D ; Sitzia C ; Cassinelli L ; Del Fraro G ; Razini P ; Angeloni V ; Jardim L ; da Silva Bizario J ; Garcia L ; Torrente I | AFM-TELETHON | 2011In DMD, skeletal and cardiac muscles are affected, leading to wheelchair dependency, respiratory failure and premature death. Recent advances have pointed out a variety of possible therapeutic approaches. A combination of these strategies might [...]Article
Accès au résumé PubMed / to PubMed abstractArticle
AFM-TELETHON 2011Embryonic stem (ES) cells differentiate into multiple lineages during in vitro embryoid body (EB) formation. This makes the ES/EB system a powerful tool to study early embryonic developmental pathways and to generate specific cell populations fo[...]