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Reco PNDS
The D2-mdx mouse model for Duchenne muscular dystrophy has gained popularity in the field, due to their more severely affected muscle function and histopathology when compared to the classic BL10-mdx model. This document describes recommended pr[...]Reco PNDS
The hanging wire tests that are described in this SOP can be used to assess global “subacute” muscle function and coordination over time in young and old mdx mice and their allelic variants in the C57BL/6J and DBA/2J genetic backgrounds. The tes[...]Reco PNDS
The objective of this SOP is to describe how treadmill or wheel running exercise can be used to aggravate the dystrophic phenotype in mdx mice to better determine the benefits, if any, of a specific treatment. Mdx mice have a less severe phenoty[...]Reco PNDS
objective is to determine the total hydroxyproline expressed per mg of muscle tissue wet weight (hydroxyproline content) as a quantitative measure of collagen deposition and fibrosis. The procedure is adapted from Prockop and Udenfriend (1960) a[...]Reco PNDS
The study of muscle diseases has evolved from a classical time in which a diagnosis was based on clinical and pathologic features, to a modern period when muscle biopsies were further characterized through histo- and cytochemical techniques, to [...]Reco PNDS
This document describes the methodology for performing isolated muscle function measurements for mouse extensor digitorum longus (EDL), soleus, and diaphragm, and provides reference values for isometric contractile properties of muscles from mdx[...]Reco PNDS
This document describes the methodology for performing measurements of muscle function on mouse tibialis anterior (TA) muscles, but the information is equally relevant for other hindlimb muscles, including the extensor digitorum longus (EDL), so[...]Reco PNDS
The measurement of muscle contractile function is an important end-point for assessing the efficacy of cell-, gene-, or pharmacologically-based therapies in DMD and the mdx mouse and GRMD dog models. Muscles in DMD and both the mdx mouse and GRM[...]Reco PNDS
Most DMD natural history studies have included measurements of muscle strength, joint contractures, and timed function tests. Results from these tests are used to track disease progression and offer insight on clinical milestones, such as the lo[...]Reco PNDS
This document describes the methodology for performing an evaluation of the respiratory system in adult C57 normal and mdx mice.Reco PNDS
The grip strength test is a simple non-invasive method designed to evaluate mouse muscle force in vivo, by taking advantage of the animal’s tendency to grasp a horizontal metal bar or grid while suspended by its tail. The bar or grid is attached[...]Reco PNDS
Ce guide traite des aspects "médicaux" d'une Dystrophie musculaire de Duchenne, tout en gardant à l'esprit que les aspects médicaux ne font pas tout en terme de qualité de vie. L'idée est qu'en minimisant les problèmes médicaux, votre enfant peu[...]Reco PNDS
This is a guide to the 'medical' aspects of Duchenne, but always bear in mind that the medical side isn't everything. The idea is that by minimizing medical problems, your child can get on with his life and you can get on with being a family. It[...]Reco PNDS
Behavioural and locomotor measurements are important parameters that help to define the phenotypes of mice with neuromuscular disorders such as muscular dystrophies. These assessments are done in an open field Plexiglas chamber equipped with mul[...]Reco PNDS
Creatine kinase (CK) is a protein found in cardiac and skeletal muscle. Serum CK levels are routinely used as an indicator of muscle damage in dystrophic mice and are even use as a diagnostic tool in human DMD. Levels of this muscle protein are [...]Reco PNDS
The objective of this SOP is to describe the procedures and provide the main guidelines for performing electrophysiological recordings by means of the patch clamp technique to investigate the cation channels involved in the increase in sarcolemm[...]Reco PNDS
The objective of this standard operating procedure (SOP) is to describe the technique of non-invasive echocardiography in the mouse model of Duchenne muscular dystrophy (DMD). Cardiomyopathy is an increasingly important aspect in the treatment o[...]Reco PNDS
The objective of this SOP is to describe how treadmill or wheel running exercise can be used to evaluate the disease-related impairment of neuromuscular function in mdx mice to better determine the benefits of a specific treatment. The ultimate [...]Article
Reco PNDS
This document describes a method and provides reference values for the histological characterisation of dystrophic muscle from mdx mice.Reco PNDS
This document describes a method and provides reference values for the quantitative and reliable measurement of pathology-relevant histological parameter of dystrophic muscle in the mdx mouse.Reco PNDS
When intrinsic left ventricular cardiac contractility is studied, it is necessary to differentiate the effects of an intervention/genotype/drug…on intrinsic contractility itself and the effects on preload, afterload and heart rate that indirectl[...]Reco PNDS
Ce guide est basé sur les recommandations d'un groupe de 82 experts internationaux spécialisés dans 7 domaines : pathologie, neurologie, pneumologie, gastro-entérologie/ nutrition / soins bucco-dentaires, orthopédie / rééducation, cardiologie, s[...]Rapport institutionnel
TREAT-NMD 10/2010Le financement de TREAT-NMD par la Commission Européenne se terminant en décembre 2011, une enquête publique a été menée sur l'impact des activités de TREAT-NMD et ses activité futures, gouvernance et sources de financement. Le résultat de cette[...]Reco PNDS
Traduction française du Guide "Standards of care for spinal muscular atrophy", basé sur le "Consensus statement for Standard of Care in Spinal Muscular Atrophy, publié dans le Journal of Child Neurology en 2007:2, p 1027.