Titre : | Correction of a pathogenic gene mutation in human embryos |
Revue : | Nature, 548, 7668 |
Auteurs : | Ma H, Auteur ; Marti-Gutierrez N ; Park SW ; Wu J ; Lee Y ; Suzuki K ; Koski A ; Ji D ; Hayama T ; Ahmed R ; Darby H ; Van Dyken C ; Li Y ; Kang E ; Park AR ; Kim D ; Kim ST ; Gong J ; Gu Y ; Xu X ; Battaglia D ; Krieg SA ; Lee DM ; Wu DH ; Wolf DP ; Heitner SB ; Belmonte JCI ; Amato P ; Kim JS ; Kaul S ; Mitalipov S |
Type de document : | Article |
Année de publication : | 2017 |
Pages : | p 413 |
Langues: | Anglais |
Mots-clés : | CRISPR/Cas9 ; diagnostic préimplantatoire ; édition génomique ; embryon ; gène MYBPC3 ; hétérozygote ; mutation génétique ; thérapie génique |
Résumé : |
Comment in:
Biotechnology: At the heart of gene edits in human embryos. [Nature. 2017] Genome editing: CRISPR-Cas becoming more human. [Nat Rev Mol Cell Biol. 2017] Genetics: Human genome editing in heart disease. [Nat Rev Cardiol. 2017] Gene therapy: Human genome editing in heart disease. [Nat Rev Genet. 2017] Biotechnology: CRISPR-Cas becoming more human. [Nat Rev Drug Discov. 2017] CRISPR: Established Editor of Human Embryos? [Cell Stem Cell. 2017] Take stock of research ethics in human genome editing. [Nature. 2017] Re: Correction of a Pathogenic Gene Mutation in Human Embryos. [J Urol. 2018] Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats. [Mol Ther. 2018] Large deletions induced by Cas9 cleavage. [Nature. 2018] Human-embryo editing, genetic privacy and Ebola returns. [Nature. 2018] Include egg donors in CRISPR gene-editing debate. [Nature. 2019] |
Pubmed / DOI : | DOI : 10.1038/nature23305 / Pubmed : 28783728 |
En ligne : | http://www.ncbi.nlm.nih.gov/pubmed/28783728 |