Title: | Safety, pharmacokinetics and sialic acid production after oral administration of N-acetylmannosamine (ManNAc) to subjects with GNE myopathy |
Journal : | Molecular genetics and metabolism, 122, 1-2 |
Authors: | Xu X, Author ; Wang AQ ; Latham LL ; Celeste F ; Ciccone C ; Malicdan MC ; Goldspiel B ; Terse P ; Cradock J ; Yang N ; Yorke S ; McKew JC ; Gahl WA ; Huizing M ; Carrillo N |
Material Type: | Article |
Publication Date: | 2017 |
Size: | p 126 |
Languages: | English |
Keywords : | adverse side effects ; double-blind studies ; drug tolerance ; GNE myopathy ; N-acetylmannosamine (ManNac) ; oral administration ; pharmacokinetics ; phase 1 clinical trials ; randomized studies ; sialic acid |
Keywords: | First-in-human study;GNE;GlcNAc kinase;N-acetylneuraminic acid;Pharmacokinetics;Sialylation; |
Pubmed / DOI : | DOI : 10.1016/j.ymgme.2017.04.010 / Pubmed : 28641925 |
Link for e-copy: | http://www.ncbi.nlm.nih.gov/pubmed/28641925 |
See also : |