Title: | Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy |
Journal : | Science translational medicine, 8, 370 |
Authors: | Polanco MJ, Author ; Parodi S ; Piol D ; Stack C ; Chivet M ; Contestabile A ; Miranda HC ; Lievens PM ; Espinoza S ; Jochum T ; Rocchi A ; Grunseich C ; Gainetdinov RR ; Cato AC ; Lieberman AP ; La Spada AR ; Sambataro F ; Fischbeck KH ; Gozes I ; Pennuto M |
Material Type: | Article |
Publication Date: | 2016 |
Languages: | English |
Keywords : | adenylate cyclase ; androgen receptor ; AR gene ; CAG triplet repeats ; cell cultures ; cyclin-dependent kinases ; mouse model ; phosphorylation ; protein kinase A ; spinal and bulbar muscular atrophy |
Pubmed / DOI : | DOI : 10.1126/scitranslmed.aaf9526 / Pubmed : 28003546 |
Link for e-copy: | http://www.ncbi.nlm.nih.gov/pubmed/28003546 |