Résumé :
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Communication n° 213. SUMMARY In the embryo and in the adult, skeletal muscle growth is dependent upon the proliferation and the differentiation of muscle progenitors present within muscle masses. Despite their prime importance, their embryonic origin is unclear. Here, we utilized the electroporation of GFP in chick somites, the video-confocal analysis of cell movements and quail-chick grafting experiments to demonstrate that the dorsal compartment of the somite, the dermomyotome, is the origin of a population of muscle progenitors that massively contribute to the growth of trunk muscles during embryonic and fetal life. Furthermore, long-term lineage analyses indicate that satellite cells, known progenitors of adult skeletal muscles, derive from the same cell population. We conclude that embryonic muscle progenitors and satellite cells share a common origin that can be traced back to the dermomyotome.
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