Titre :
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Effect of age at initiation of corticosteroids on age at loss of ambulation in patients with Duchenne muscular dystrophy (DMD) (Poster)
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contenu dans :
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Auteurs :
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Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) ;
Pandya S ;
Fox D ;
Ciafaloni E ;
Druschel C ;
Moxley R
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Type de document :
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Article
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Année de publication :
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2008
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Pages :
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p. 89
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Langues:
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Anglais
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Mots-clés :
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âge
;
âge de début de la maladie
;
colloque
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corticothérapie
;
dystrophie musculaire de Duchenne
;
étude rétrospective
;
perte de la marche
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Résumé :
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Objective : To determine the effect of age at initiation of corticosteroids on age at loss of ambulation in patients with Duchenne muscular dystrophy (DMD) Background : The hypothesis among clinicians is that earlier the initiation of corticosteroids, the greater the benefit on prolongation of ambulation. No data is available to provide support for this hypothesis. Methods : We retrospectively analyzed data on all boys followed at our site since 1991 to look at the effect of age at initiation of corticosteroids on the age at loss of ambulation. We categorized the boys as follows: 1) Never treated with corticosteroids and 2) treated with corticosteroids. 2) Treated group was subdivided into 3 categories based on age at initiation of steroids as follows: Group a) age 4 to <7 years; b) age 7 to <9 years: c) 9 to <13 years. Results : Complete follow up data was available on 68 boys. 21 boys had never been treated with corticosteroid and ceased ambulation at an average age of 8 years. Of the 47 treated boys: Group a) N =24 initiated treatment at age 6.1( sd 0.7 yrs) and ceased ambulation at age 13.5 (sd 3.3 yrs) Group b) N=14 initiated treatment at age 7.8 (sd 0.6 yrs) and ceased ambulation at age 13.5 (sd 2.5. yrs) Group c) N=9 initiated treatment at age 10.3 (sd 0.6 yrs) and ceased ambulation at age 12.8 (sd 2.5 yrs) The results between the 3 groups categorized by age at initiation of treatment were not statistically significant. This may be due to the small sample sizes. Conclusions : Retrospective data from our site demonstrates a trend that earlier the age (<9yrs) at initiation of corticosteroid the greater the prolongation of ambulation.
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