Résumé :
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In order to determine the role of growth factors, cytokines and chemokines in the physiopathology of muscle disease we have compared the level of expression of 174 factors in both the affected and non affected muscles of Oculo-Pharyngeal Muscular Dystrophy (OPMD) patients by means of antibodies arrays. OPMD is characterized by progressive eyelid drooping (ptosis) and swallowing difficulties (dysphagia). The pharyngeal and cricopharyngeal muscles (CP) are specific targets in OPMD. In the present study expression of 174 factors in CP (affected) muscle was compared versus Sternocleidomastoid (SCM) (spared) muscles in 8 OMPD patients. We found an important individual variability in the expression of some factors in affected and spared muscles. Nevertheless, the expression of sixty factors was persistently different between these two groups. Many of the differentially expressed factors in our study are known to be involved in the formation of fibrosis in both the liver and the lung, thus indicating the possibility that the treatment used in hepatic fibrosis may have a beneficial effect in OPMD.
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