Title: | Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition |
Journal : | Human molecular genetics, 18, 2 |
Authors: | Hauke J ; Riessland M ; Lunke S ; Eyupoglu IY ; Blumcke I ; El-Osta A ; Wirth B ; Hahnen E |
Material Type: | Article |
Publication Date: | 2009 |
Size: | p. 304-317 |
Languages: | English |
Keywords : | disease severity ; histone deacetylase ; histone deacetylase inhibitors ; methylation ; molecular genetics ; phenylbutyric acid ; silencers (genetics) ; SMN2 gene ; spinal muscular atrophy ; valproic acid |
Abstract: |
Accès au résumé PubMed / to PubMed abstract |
Lien associé : | http://www.ncbi.nlm.nih.gov/pubmed/18971205?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum |
Pubmed / DOI : | DOI : 10.1093/hmg/ddn357 |