Résumé :
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Objective : We assessed the effect of exercise training and non-invasive ventilation (NIV) applied during exercise on exercise tolerance and quality of life in patients with restrictive disorders. Design : Sixteen patients (TLC 55% predicted) underwent an 8-week home-based cycle exercise program. Nine patients were randomized to exercise with NIV and 7 without. Before and after training, evaluations included an incremental and a constant-load cycling test, a 6-min walking test and completion of the Chronic Respiratory Questionnaire (CRQ). Results : For the whole group, training increased walking distance (+22±35m), maximal cycling power output (+5±9W), cycling endurance (+75±94%) and CRQ score (+10±13pts). These changes did not differ between patients training with or without NIV. However, in patients increasing cycling endurance with NIV by >50% before training (n=10), training with NIV induced greater improvement in walking distance (+48±31 vs. +12±24m) and CRQ score (+15±15 vs. -2±2 pts). Conclusions : We concluded that in patients with restrictive disorders i) exercise training including NIV is feasible at home, ii) whatever the modalities, exercise training induces significant benefits in exercise tolerance and quality of life, and iii) in acute NIV responders, chronic use of NIV during exercise may lead to a synergetic effect compared to traditional training.
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