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Myobank-AFM at the Institut de Myologie: human tissue samples and byproducts at the disposal of the scientists in the field of neuromuscular diseases.Thomas Voit Maud Chapart Stane VasseurThe AFM tissue bank for research was created in 1996. It is a non-profit professional service for scientific teams. Its scope is to provide them with the necessary tissue samples in the best possible conditions and offer them a secure storage site to accommodate their biological-sample collections. Its staff collects the samples, prepares the tissues, stores them or organizes their transportation according to the needs of the scientists.Myobank examines the requests and checks that they meet the current ethical and deontology criteria concerning the collection and use of human tissue.If the number of requests is higher than the available amount of tissue, the research subject conditions the priority. Subjects supported by the AFM (rare diseases and neuromuscular diseases) have priority. Requests outside this field are submitted to the approval of the Medical and Scientific Director of the Association Institut de Myologie. Request The President of the Myobank Scientific Committee analyzes the request. The role of Myobank is to provide the samples required by the researchers as fast as possible. In order to reach this goal, if there are no available samples in store, Myobank activates its network of collaborating doctors to collect the missing samples.SampleThe sampling of human tissues or cells is carried out by doctors, who collect the following: surgical remains, collected towards the end of surgery samples carried out within a precise clinical research protocol, in accordance with the Huriet lawPreparationThe sample is packaged according to its expected use in order to maintain the intrinsic tissue quality.The various preparations carried out at Myobank allow: Cell cultures Biochemical studies Studies requiring morphological preservation The follow-up and transmission of information related to the sample are ensured by the GBC database.NewsA few research projects:Collection of muscle for the provision of myoblasts (Genethon, Myosix, cell platform of the AIM)MYOAGE : Understanding and combating age-related muscle weaknessJT VIlquin : Production, carachterization, differentiation of human normal and pathological skeleton and muscle cellsB Constantin : TRPC-dependent calcium influx and regulation by syntrophin : Involvement in DMD human muscle cells
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