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Auteur Hagège A |
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Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies
Wahbi K, Ben Yaou R, Gandjbakhch E, et al.
Circulation, 2019
Voir aussi
Letter by Aimo et al Regarding Article, "Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies"
Aimo A, Barison A, Emdin M
Circulation, 2019, 140, 23
Letter by Barriales-Villa et al Regarding Article, "Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies"
Barriales-Villa R, Larranaga-Moreira JM, Ochoa JP
Circulation, 2019, 140, 23
Avis des lecteurs Aucun avis, ajoutez le vôtre !
(mauvais) 15 (excellent)
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Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report
Menasché P, Vanneaux V, Hagège A, et al.
European heart journal, 2015, 36, 30, p 2011
Revue : European heart journal, 36, 30 Titre : Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report Type de document : Article Auteurs : Menasché P, Auteur ; Vanneaux V ; Hagège A ; Bel A ; Cholley B ; Cacciapuoti I ; Parouchev A ; Benhamouda N ; Tachdjian G ; Tosca L ; Trouvin JH ; Fabreguettes JR ; Bellamy V ; Guillemain R ; Suberbielle Boissel C ; Tartour E ; Desnos M ; Larghero J Année de publication : 2015 Pages : p 2011 Langues : Anglais (eng) Mots-clés : cellule souche embryonnaire ; différenciation cellulaire ; étude de cas ; étude transversale ; fibre musculaire cardiaque ; insuffisance cardiaque ; personne âgée ; thérapie cellulaire Pubmed / DOI : DOI : 10.1093/eurheartj/ehv189 / Pubmed : 25990469
En ligne : http://www.ncbi.nlm.nih.gov/pubmed/25990469 Avis des lecteurs Aucun avis, ajoutez le vôtre !
(mauvais) 15 (excellent)
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Myoblast transplantation in heart failure : the MAGIC study
Vilquin JT, Marolleau JP, Hagège A, et al.
Congrès : Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France)
2008, p. 25
Titre : Myoblast transplantation in heart failure : the MAGIC study Type de document : Article Auteurs : Marolleau JP ; Hagège A ; Larghero J ; Schwartz K ; Menasché P Congrès : Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) Année de publication : 2008 Pages : p. 25 Langues : Anglais (eng) Mots-clés : collaboration scientifique ; colloque ; essai clinique de phase 1/2 ; insuffisance cardiaque ; myoblaste ; transplantation cellulaire Résumé : Cell grafting is a potential approach to improve cardiac healing and limit the progression of heart failure, which is characterized by a rapid and irreversible loss of cardiomyocytes. Many cell types have been tested. Myoblasts, being skeletal muscle progenitors, present advantages: easiness of collection, large expansion capacity, resistance to ischemia, and autologous origin. Pre-clinical results in several animal models prompted the set-up of phase I and phase II clinical trials, therefore procedures were established for producing human myoblasts for clinical use. The long-term follow-up of the historical first phase I cohort of patients indicated that clinical status and LV function stably improved over time along with a strikingly low incidence of hospitalizations, and that the arrhythmic risk was controlled by medical therapy and/or implanted cardioverter defibrilator (ICD). Given the encouraging results, the Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) phase II trial was designed to assess the safety, efficacy, and impact on general status, of high (800x106) and low (400x106) doses of myoblasts, as compared to placebo. Ninety-seven patients received treatment as adjunct to bypass surgery, and an ICD. This double blind randomized study was conducted in 21 academic hospitals in France, Germany, Belgium, United Kingdom and Italy from 01/2003 to 02/2006. The six-month follow-up demonstrated the absence of statistically increased risk of major adverse cardiac events or ventricular arrythmias (in this small sample), the absence of significant improvement of regional or global contractility (echocardiography), and the evidence for significant reversal of remodeling, an important predictor of clinical outcome (decreased LVED and LVES volumes). This approach may represent the first generation of cell therapy products for use in cardiac failure. Research ways aim at refining the indications, improving the delivery systems, and considering associations of cell types with supporting biomaterials or growth factors. Supported by : Assistance Publique Hopitaux de Paris, Genzyme SA, AFM, Inserm. Avis des lecteurs Aucun avis, ajoutez le vôtre !
(mauvais) 15 (excellent)
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Diagnostic accuracy of a 2D left ventricle hypertrophy score for familial hypertrophic cardiomyopathy.
Forissier J-F, Charron P, Tezenas du Montcel S, et al.
European heart journal, 2005, 26, 18, p. 1882-1886
Revue : European heart journal, 26, 18 Titre : Diagnostic accuracy of a 2D left ventricle hypertrophy score for familial hypertrophic cardiomyopathy. Type de document : Article Auteurs : Forissier J-F ; Charron P ; Tezenas du Montcel S ; Hagège A ; Isnard R ; Carrier L ; Richard P ; Desnos M ; Bouhour JB ; Schwartz K ; Komajda M ; Dubourg O Année de publication : 2005 Pages : p. 1882-1886 Langues : Anglais (eng) Mots-clés : recherche biomédicale Avis des lecteurs Aucun avis, ajoutez le vôtre !
(mauvais) 15 (excellent)
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Can cold or heat shock improve skeletal myoblast engraftment in infarcted myocardium?
Maurel A, Azarnoush K, Sabbah L, et al.
Transplantation, 2005, 80, p. 660-665
Revue : Transplantation, 80 Titre : Can cold or heat shock improve skeletal myoblast engraftment in infarcted myocardium? Type de document : Article Auteurs : Maurel A ; Azarnoush K ; Sabbah L ; Vignier N ; Le Lorc'h M ; Mandet C ; Bissery A ; Garcin I ; Carrion C ; Fiszman M ; Bruneval P ; Hagège A ; Carpentier A ; Vilquin JT ; Menasché P Année de publication : 2005 Pages : p. 660-665 Langues : Anglais (eng) Mots-clés : recherche biomédicale Résumé :
Accès au résumé PubMed / to PubMed abstractLien associé : http://www.ncbi.nlm.nih.gov/pubmed/16177642 Avis des lecteurs Aucun avis, ajoutez le vôtre !
(mauvais) 15 (excellent)
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Comparison of human skeletal myoblasts and bone marrow-derived CD133+ progenitors for the repair of infarcted myocardium
Agbulut O, Vandervelde S, Al Attar N, et al.
Journal of the American College of Cardiology, 2004, 44, 2, p. 458-463
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Transplantation of adult skeletal muscle cells in the heart
Vilquin JT, Marolleau JP, Pouzet B, et al.
Acta myologica, 2001, XX, p. 145-150
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Evolution d'une myocardiopathie hypertrophique obstructive vers une myocardiopathie dilatée. A propos de 4 cas
Bourmayan C, Desnos M, Baragan J, et al.
Archives des maladies du coeur et des vaisseaux, 1990, 83, 4, p. 537-542
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