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Auteur Bernheim L |
Documents disponibles écrits par cet auteur (18)
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Xèmes Journées Annuelles de la Société française de Myologie (SFM) (14-16 novembre 2012; Grenoble (France)) ; Antigny F ; Bernheim L ; Frieden M | Société Française de Myologie SFM | 2012Myogenesis process involves the expression of muscle-specific transcription factors such as myogenin and MEF2 (myocyte enhancer factor 2), and is fundamentally regulated by intracellular Ca2+ fluctuations. Both ER Ca2+ release and Ca2+ entry gen[...]Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Leroy M ; Darbellay B ; Bernheim L ; Konig S | AFM-TELETHON | 2011Our work focuses on the comprehension of the early steps of myoblast differentiation. The model we use consists of a human myoblast culture derived from satellite cells extracted from muscle biopsies. We previously showed that, to differentiate,[...]Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Konig S ; Brawand P ; Bernheim L | AFM-TELETHON | 2011Our work is based on human primary myoblast cultures derived from single satellite cells. In human, as in other species, it is well established that myoblast differentiation is mainly controlled by two families of transcription factors, the Myog[...]Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Darbellay B ; Konig K ; Arnaudeau S ; Bader C ; Bernheim L | 2011Cytosolic Ca2+ signals encoded by repetitive Ca2+ releases rely on two processes to refill Ca2+ stores: (i) Ca2+ re-uptake from the cytosol and (ii) activation of a Ca2+ influx via Store Operated Calcium Entry (SOCE). SOCE activation is, however[...]Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Fabrice A ; Konig S ; Bernheim L ; Frieden M | 2011The myogenesis process involves the expression of muscle-specific transcription factors such as myogenin and MEF2, and is essentially regulated by fluctuations of the cytosolic Ca2+ concentration. Previous work demonstrated that hyperpolarizatio[...]Article
Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) ; Laumonier T ; Konig S ; Bader C ; Bernheim L ; Hoffmeyer P ; Menetrey J | 2008Cellular therapies for Duchenne muscular dystrophy and other muscle diseases are limited by a massive early cell death following injections. The quantification of cell survival is an essential step to evaluate the efficiency of myoblast transpla[...]Article
Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) ; Konig S ; Bader CR ; Bernheim L | 2008Our work is based on human primary myoblast cultures derived from single satellite cells. Human myoblasts are able to proliferate for several weeks in culture, and terminal differentiation into myotubes can be induced by serum withdrawal. In hum[...]Article
Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) ; Hinard V ; Leroy M ; Bader CR ; Bernheim L | 2008Myoblasts are mononucleated cells that fuse together to form skeletal muscle fibers. We have shown previously that human myoblast differentiation requires a hyperpolarization of the resting membrane potential to take place. This hyperpolarizatio[...]Article
VIes Journées annuelles de la Société Française de Myologie (SFM) (22-23 octobre 2008; Lausanne (Suisse)) ; Bernheim L | 2008Postnatal myogenesis, which occurs during muscle repair after a lesion, relies on the activation of myogenic stem cells (muscle satellite cells). Activated satellite cells proliferate as myoblasts that have the ability of migrating to the lesion[...]Article
Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) ; Darbellay B ; Arnaudeau S ; Konig S ; Jousset H ; Bader CR ; Demaurex N ; Bernheim L | 2008Specific intracellular calcium signals are required to induce myoblast differentiation. To generate these calcium signals, myoblasts can rely on two major sources: releases from intracellular calcium stores and influxes from extracellular medium[...]Article
Congrès international de myologie 2005 (International Congress of Myology 2005; 9-13 mai 2005; Nantes, France) ; Hinard V ; Konig S ; Bader C ; Bernheim L | 2005Communication n° 155. During post-natal growth or after muscle injury, skeletal muscle myoblasts differentiate and fuse to form myotubes. We have shown recently that one of the earliest events of the differentiation is the hyperpolarization of h[...]Article
Congrès international de myologie 2005 (International Congress of Myology 2005; 9-13 mai 2005; Nantes, France) ; Arnaudeau S ; Holzer N ; Konig S ; Bader CR ; Bernheim L | 2005Communication n° 137. Myoblast differentiation is a strictly Ca2+-dependent process. We have shown that a main route for Ca2+ entry is through T-type Ca2+ channels. However, because of the importance of cytoplasmic Ca2+ for differentiation, myob[...]Article
Congrès international de myologie 2005 (International Congress of Myology 2005; 9-13 mai 2005; Nantes, France) ; Konig S ; Hinard V ; Beguet A ; Arnaudeau S ; Bader CR ; Bernheim L | 2005Communication n° 144. We have showed previously that human myoblasts must hyperpolarize to approximately -70 mV before they can proceed through the differentiation process. This hyperpolarization occurs through the expression of Kir2.1 K+ channe[...]Article
Liu JH ; Konig S ; Michel M ; Arnaudeau S ; Fischer-Lougheed J ; Bader CR ; Bernheim L | 2003Article
Bernheim L ; Hamann M ; Liu JH ; Fischer-Lougheed J ; Bader CR | 1996Si l'on sait depuis longtemps que les récepteurs nicotiniques de l'acétylcholine (nAchRs) sont présents dans les fibres musculaires à la jonction myotendineuse, leur fonction est cependant jusqu'à présent inconnue. De récentes expériences menées[...]Article
Magistris MR ; Kohler A ; Pizzolato GA ; Morris MA ; Baroffio A ; Bernheim L ; Bader CR | 02/98Les auteurs décrivent leur méthode de biopsie à l’aiguille, qu’ils ont testée auprès de 220 patients présentant différentes maladies neuromusculaires. Ils mettent en avant sa bonne tolérance, les patients n’ayant jamais refusé de se faire prélev[...]