Résumé :
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The High Throughput Screening (HTS) activity is part of the drug discovery process, and consists in selecting among thousands of molecules the ones that could have a pharmaceutical use. To do that, large compounds libraries are tested on a biological model showing a specific therapeutic target. The HTS at I-Stem focuses on relevant biological models of genetic diseases: the human stem cells and their progenies. The self-renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells…), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.
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