Title: | Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study |
Journal : | PLoS ONE, 11, 1 |
Authors: | Hafner P, Author ; Bonati U ; Erne B ; Schmid M ; Rubino D ; Pohlman U ; Peters T ; Rutz E ; Frank S ; Neuhaus C ; Deuster S ; Gloor M ; Bieri O ; Fischmann A ; Sinnreich M ; Gueven N ; Fischer D |
Material Type: | Article |
Publication Date: | 2016 |
Languages: | English |
Keywords : | arginine ; body composition ; calorimetry ; chemokines ; children ; Duchenne muscular dystrophy ; energy metabolism ; ibuprofen ; lipid metabolism ; metformin ; mitochondria ; Motor Function Measure (MFM) ; MRI ; muscle biopsies ; muscle function ; NO synthase ; oxidative stress ; pilot trials ; respiratory chain ; therapeutic prospects |
Pubmed / DOI : | DOI : 10.1371/journal.pone.0147634 / Pubmed : 26799743 |
Link for e-copy: | http://www.ncbi.nlm.nih.gov/pubmed/26799743 |