Résumé :
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The general objective of cell therapy techniques is to replace population of deficient cells to restore the functions of damaged tissue due to disease or traumatism. Cell therapy technologies and methods have already beed developed for muscle disease. In order to transform this first set of results into an efficient therapy aiming to restore muscle function many hurdles must be overcome. This concerns: o A better definition of mechanisms leading to muscle deficiency o Identifications of diverse sources of cells that can be efficiently use to rebuild muscle o The design and the validation of technologies that will allow production of cell therapy agents in a clinically relevant GMP conditions o The design and the validation of technologies that will allow safe , little invasive, widespread injection of therapeutical cells in patients o The approval by regulatory authorities of clinical trials in order to demonstrate the relevance of the research and the development carried. These points will be discussed in the light of recent advances in muscle basic biology, in preclinical models, in the definition of biomarkers, in automation engineering and in clinical trails.
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