Résumé :
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Our group is focused on two closely interconnected research lines, aiming to increase the understanding of the molecular mechanisms controlling skeletal muscle regeneration, as well as fibrosis development in dystrophinopathies. Specifically, our goals are:1- To gain insight into the mechanisms regulating satellite cell behaviour during muscle regeneration, centering our attention on the p38 MAPK signaling pathway.2- To investigate the inflammatory pathways that may lead to either efficient muscle repair or fibrosis development, particularly during Duchenne Muscular Dystrophy (DMD). Besides progressive muscle degeneration and inflammation, fibrotic transition of muscle tissue is a critical aggravating process in DMD. We will discuss our recent findings on both research lines. This work was supported by AFM, MICINN, EU and CIBERNED.
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