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Lilien C, Gasnier E, Gidaro T, et al.
Journal of visualized experiments : JoVE, 2019, n 150
Revue : Journal of visualized experiments : JoVE, n 150 Titre : Home-Based Monitor for Gait and Activity Analysis Type de document : Article Auteurs : Lilien C, Auteur ; Gasnier E ; Gidaro T ; Seferian A ; Grelet M ; Vissière D ; Servais L Editeur : United States Année de publication : 08/2019 Langues : Anglais (eng) Pubmed / DOI : Pubmed : 31449251 / DOI : 10.3791/59668 N° Profil MNM : 2019091 En ligne : http://www.ncbi.nlm.nih.gov/pubmed/31449251
A Movement Monitor Based on Magneto-Inertial Sensors for Non-Ambulant Patients with Duchenne Muscular Dystrophy: A Pilot Study in Controlled Environment.Le Moing AG, Seferian AM, Moraux A, et al.
PLoS ONE, 2016, 11, 6, 17 p.
Revue : PLoS ONE, 11, 6 Titre : A Movement Monitor Based on Magneto-Inertial Sensors for Non-Ambulant Patients with Duchenne Muscular Dystrophy: A Pilot Study in Controlled Environment. Type de document : Article Auteurs : Le Moing AG ; Seferian AM ; Moraux A ; Annoussamy M ; Dorveaux E ; Gasnier E ; Hogrel JY ; Voit T ; Vissière D ; Servais L Année de publication : 07/06/2016 Pages : 17 p. Langues : Anglais (eng) Mots-clés : dynamométrie ; dystrophie musculaire de Duchenne ; essai pilote ; étude d'évaluation ; poignet ; reproductibilité des résultats Résumé : Measurement of muscle strength and activity of upper limbs of non-ambulant patients with neuromuscular diseases is a major challenge. ActiMyo(R) is an innovative device that uses magneto-inertial sensors to record angular velocities and linear accelerations that can be used over long periods of time in the home environment. The device was designed to insure long-term stability and good signal to noise ratio, even for very weak movements. In order to determine relevant and pertinent clinical variables with potential for use as outcome measures in clinical trials or to guide therapy decisions, we performed a pilot study in non-ambulant neuromuscular patients. We report here data from seven Duchenne Muscular Dystrophy (DMD) patients (mean age 18.5 +/- 5.5 years) collected in a clinical setting. Patients were assessed while wearing the device during performance of validated tasks (MoviPlate, Box and Block test and Minnesota test) and tasks mimicking daily living. The ActiMyo(R) sensors were placed on the wrists during all the tests. Software designed for use with the device computed several variables to qualify and quantify muscular activity in the non-ambulant subjects. Four variables representative of upper limb activity were studied: the rotation rate, the ratio of the vertical component in the overall acceleration, the hand elevation rate, and an estimate of the power of the upper limb. The correlations between clinical data and physical activity and the ActiMyo(R) movement parameters were analyzed. The mean of the rotation rate and mean of the elevation rate appeared promising since these variables had the best reliability scores and correlations with task scores. Parameters could be computed even in a patient with a Brooke functional score of 6. The variables chosen are good candidates as potential outcome measures in non-ambulant patients with Duchenne Muscular Dystrophy and use of the ActiMyo(R) is currently being explored in home environment. TRIAL REGISTRATION: ClinicalTrials.gov NCT01611597. Pubmed / DOI : DOI : 10.1371/journal.pone.0156696 / Pubmed : 27271157 En ligne : http://www.ncbi.nlm.nih.gov/pubmed/27271157
PLoS_One_2016,_11(6)e156696,_p._1-17.pdfAdobe Acrobat PDF
A phase I/IIa Clinical Trial in Duchenne Muscular Dystrophy using systemically delivered morpholino antisense oligomer to skip exon 53 (SKIP-NMD)Muntoni F, Voit T, Servais L, et al.
Human gene therapy. Clinical development, 2015, p. 92-95
Revue : Human gene therapy. Clinical development Titre : A phase I/IIa Clinical Trial in Duchenne Muscular Dystrophy using systemically delivered morpholino antisense oligomer to skip exon 53 (SKIP-NMD) Type de document : Article Auteurs : Muntoni F, Auteur ; Voit T, Auteur ; Servais L, Auteur ; Baudin PY, Auteur ; Straub V, Auteur ; Mercuri E, Auteur ; Bain J, Auteur ; Dickson G, Auteur ; Vissière D, Auteur ; Dorveaux E, Auteur ; Kaye EM, Auteur ; Duda P, Auteur ; van't W Hoff, Auteur Année de publication : 2015 Pages : p. 92-95 Langues : Français (fre) Mots-clés : dystrophie musculaire de Duchenne ; essai clinique de phase 1/2 ; morpholino ; saut d'exon Pubmed / DOI : Pubmed : 10.1089/humc.2015.2528Béré E, Benoit M, Vissière D, et al.
Congrès : 4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France))
2011, p. 132
Titre : Actimetry and neuromuscular disorders : a system suitable for upper limb evaluation (poster) Type de document : Article Auteurs : Benoit M ; Vissière D ; Duchêne J ; Hogrel JY ; Servais L Congrès : 4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) Année de publication : 2011 Pages : p. 132 Langues : Anglais (eng) Mots-clés : colloque Résumé : There is currently no standardized method to assess upper limb activity in non-ambulatory patients. Actimetry, with use of motion sensors, are probably the most promising method. Indeed, it provides continuous monitoring of specific part of body whose movement is being studied. Moreover, it offers the opportunity to be used in free-living environment for longitudinal follow-up. The main objective of this study is to develop an actimetric method for the movement characterization of upper limbs. However, we still have to demonstrate that pertinent indicators of upper limb functional activity can be obtained from sensors output. We used a prototype integrating three-axis accelerometer, gyroscope and magnetometer. This device measures accelerations, angular velocities, magnetic field and gives an estimation of spatial orientation. Several healthy subjects were asked to perform the validated task Box & Block Test while wearing the device on the wrist of dominant hand. They were also asked to perform a task representative of daily life: typing a predefined text on a computer, score being the number of characters typed in one minute. Each test was repeated fifty times with various velocities. Then, signals captured by sensors were processed to obtain parameters representing angular velocity and acceleration magnitudes. The angles were used to dissociate gravity effect from acceleration due to real movement. Lastly, computed parameters were plotted with the scores obtained in the different tasks. For each task, exponential regressions indicate a strong correlation between average acceleration magnitude and corresponding scores (R=0.95). In the same way, linear regression indicates a strong correlation between average angular velocities magnitude and corresponding scores (R=0.97). Consequently all these results suggest that subject's efficiency could be well predicted by accelerations and angular velocities in some validated and daily life tasks. In conclusion, this preliminary study demonstrates that clinically meaningful indicators can be extracted from sensors output to predict the functional status of the upper limbs. This could be further applied to non ambulatory patients.