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Auteur Dorchies O |
Documents disponibles écrits par cet auteur (10)
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Article
Compte tenu des coûts importants du développement clinique de nouvelles molécules et de la lenteur de la découverte de nouveaux traitements, repositionner un médicament « ancien » dans une nouvelle indication s’avère parfois une solution intéres[...]Article
5th International Congress of Myology (14-18 March 2016; Centre convention, Lyon, France), Collectivité éditrice ; Dorchies O, Auteur ; Argov Z, Auteur ; Nishino I, Auteur ; Ferreiro A, Auteur | AFM-TELETHON | 16/03/2016Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Mohamed Ismail H ; Petterman O ; Dorchies O ; Ruegg U | AFM-TELETHON | 2011Duchenne muscular dystrophy (DMD) is a progressive disease characterized by the absence of dystrophin due to a defect in the p21 band of the X chromosome. Lack of dystrophin expression causes muscle degeneration by a mechanism that remains elusi[...]Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Dorchies O ; Gallo C ; Reutenauer-Patte J ; Ismail HM ; Gayi E ; Petermann O ; Patthey-Vuadens O | 2011Duchenne muscular dystrophy (DMD) is a fatal muscle disorder caused by the absence of dystrophin and characterized by progressive muscle wasting. Oxidative stress and excessive calcium influx are thought to contribute to the pathogenesis. Indeed[...]Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Dorchies O ; Reutenauer-Patte J ; Montet X ; Patthey-Vuadens O ; Ruegg U | 2011DMD is a fatal muscle disorder caused by the absence of dystrophin and characterized by progressive muscle wasting. Weakness of the back muscles often causes postural alterations, impairing patients' respiratory function. Oxidative stress likely[...]Article
4th International Congress of Myology, 4ème colloque international de Myologie (9-13 mai 2011; Lille (France)) ; Dorchies O ; Reutenauer-Patte J ; Petermann O ; Patthey-Vuadens O ; Gayi E ; Ruegg U | 2011To date, no cure exists for Duchenne muscular dystrophy, a fatal muscle disorder. Recently, we evaluated tamoxifen (TAM), a selective estrogen receptor modulator (SERM), used to treat certain breast cancers, on the mdx5Cv dystrophic mouse. We fo[...]Article
Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) ; Dorchies O ; Comyn S ; Ruegg U | 2008Muscular dystrophies are characterized by fibrosis, a process leading to abnormal accumulation of materials of fibroblastic origin in the skeletal muscles as necrosis-regeneration cycles take place. Fibrosis results from alterations in a multifa[...]Article
Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) ; Dorchies O ; Reutenauer J ; Vuadens O ; Comyn S | 2008Data from the literature indicate that tamoxifen (Tam), a selective estrogen receptor modulator (SERM) used in the treatment of certain types of breast cancers, displays antioxidant, anti-apoptotic and anti-fibrotic properties and stabilises bio[...]Article
Congrès international de myologie 2008 (International Congress of Myology 2008; 26-30 mai 2008; Marseille, France) ; Reutenauer J ; Dorchies O ; Boittin FX ; Patthey-Vuadens O | 2008Urocortins are structurally related peptides of the corticotrophin-releasing factor (CRF), which has been widely implicated in responses to physical, emotional and environmental stress. Recently, it has been reported that a CRF-receptor-2 (CRFR2[...]Article
Colloque jeunes chercheurs (7 mars 2008; EVRY - Centre conférence Génocentre Evry) ; Reutenauer J ; Dorchies O ; Boittin FX ; Patthey-Vuadens O ; Ruegg U | 2008Urocortins are structurally related peptides of the corticotrophin-releasing factor (CRF), which has been widely implicated in responses to physical, emotional and environmental stress. Recently, it has been reported that a CRF-receptor-2 (CRFR2[...]